No official dosing advice has been provided, however, doses of 500 2000 mg per day are typically used
This decline can show up in the form of decreased energy, slower recovery after exercise, and changes in the appearance of our skin
However, there are also studies showing that the accumulation of zinc in mitochondria can increase mitochondrial ROS (mtROS) levels and subsequently activate the downstream signaling molecule nuclear transcription factor-kappa B (NF-B) [30]
Porokhovnik LN, cape BM, yaeo A, Chudakova YuM, Ershova ES, Veiko NN, Gorbachevskaya NL, Mamokhina U, Sorokin A, Basova AY, Lapshin MS, Izhevskaya VL, Kostyuk SV (2023) Association of NEF2L2 Rs35652124 polymorphism with Nrf2 induction and genotoxic stress biomarkers in autism
It's needed to make active thyroid hormone, so a deficiency 22 means you have less active thyroid hormone and more hypothyroid symptoms